Belastung mit freien Radikalen und Stickoxiden in E-Zigaretten geringer als in Tabakzigaretten (01.04.2019)

 


In der Studie: Comparison of Free Radical Levels in the Aerosol from Conventional Cigarettes, Electronic Cigarettes, and Heat-Not-Burn Tobacco Products von Mikhail Shein and Gunnar Jeschke aus dem Jahre 2019 wurde nachgewiesen das die Belastung mit Stickoxiden und freien Radikalen in dem Dampf  E-Zigaretten deutlich geringer ist als im Rauch von Pyros.
Ähnliches gilt auch für sogenannte Heat-Not-Burn-Produkte. Welche im Rahmen dieser Studie auch getestet wurden.

5. Conclusion

We have compared levels of free radicals and NO in the gas phase of aerosol as well as of persistent radicals in total particulate matter between the 3R4F research cigarette, two e-cigs, and an HNB tobacco product by using spin-trapping techniques and EPR spectroscopy. We have applied standardized smoking and vaping regimes, reduced a number of factors that influence variability of the data, and have replicated our measurements. Signals from the research cigarette were found to be sufficiently strong for reliable quantification. For all vaping products, signals were of the same order of magnitude as the background signals, except for the NO level from the HNB tobacco product. The NO level in solutions of whole smoke increases with time for the research cigarette and remains constant for the HNB product. Considering this variation, the NO level of the HNB product is between 5.5 and 7.3% of that of the 3R4F cigarette.
Estimates of free radical level in the gas phase were obtained with PBN trapping in toluene and suggest that this level is reduced by 99% or more in the e-cigs and the HNB product compared to the 3R4F cigarette.
Similar amounts of TPM were found in all products, with the one for MESH being slightly higher and the ones for IQOS and Solaris being slightly lower than the one of 3R4F research cigarettes. However, only the TPM from the research cigarette contained persistent free radicals at a level that could be reliably distinguished from the background. Radical levels of the other products are below 7% of the level observed for the 3R4F cigarette.
Our findings demonstrate that free radicals levels are substantially reduced in e-cigarettes and heat-not-burn products compared to conventional cigarettes. A similar reduction of other HPHCs has been found before by other techniques. This supports the view that e-cigarettes and heat-not-burn products are a potentially less harmful alternative to cigarette smoking, although we maintain that toxicological studies are required to draw firm conclusions. We believe that our results can guide such studies and help in their interpretation.



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